Renal allograft pathology with C4d immunostaining in patients with graft dysfunction

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Comparison of C4d immunostaining methods in renal allograft biopsies.

Immunostaining of renal allograft biopsies for C4d deposition has become an important diagnostic tool in the recognition of humoral-mediated graft rejection. The majority of studies have been performed on frozen tissue sections with one of several commercially available antibody reagents. However, only a single small series that compared reagents or methods, including staining of formalin-fixed...

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Immunohistochemical Scoring of C4d in Egyptian Patients with Chronic Renal Allograft Dysfunction

C4d is a degradation product of complement component C4. Since the beginning of the current century, C4d has been used as a marker of acute antibody mediated rejection in renal allograft and considered as an ominous portent for poor graft survival. The ninth Banff meeting emphasized the value of C4d in renal allograft biopsy assessment and adopted a grading system for the staining degree of C4d...

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Risk factors of long-term graft loss in renal transplant recipients with chronic allograft dysfunction.

OBJECTIVES Graft loss owing to chronic allograft dysfunction is a major concern in renal transplant recipients. We assessed the affect of immune and nonimmune risk factors on death-censored graft loss in renal transplant recipients with chronic allograft dysfunction. MATERIALS AND METHODS We performed a retrospective, single-center study on 214 renal transplant recipients with chronic allogra...

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ژورنال

عنوان ژورنال: Indian Journal of Nephrology

سال: 2012

ISSN: 0971-4065

DOI: 10.4103/0971-4065.98793